Recent federal regulations affecting small businesses
Page 91 of 145 • Last updated April 16, 2026
2165 new federal regulations affecting small businesses have been published in the past 30 days, drawn from the Federal Register, FDA recalls, and USDA notices. Each listing links straight to the official source so you can read the full text and respond if it touches your business.
- Agency Information Collection Activities; Proposed Collection; Comment Request; Orphan DrugsApril 16, 2026
The FDA seeks public comment on information collection requirements for orphan drugs; the 60-day comment period begins with this Federal Register notice.
- Determination of Regulatory Review Period for Purposes of Patent Extension; UNLOXCYTApril 16, 2026
FDA determines the regulatory review period for UNLOXCYT patent extension eligibility under patent term extension law for human biological products.
- Agency Information Collection Activities; Proposed Collection; Comment Request; Importation of Prescription DrugsApril 16, 2026
FDA requests 60-day public comment period on information collection requirements for its prescription drug importation regulation under the Paperwork Reduction Act.
- International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products; Stability Testing for Medicated Premixes (Revision 1); Draft Guidance for Industry; AvailabilityApril 16, 2026 • Impact: low
FDA publishes draft guidance (VICH GL8(R1)) for stability testing of medicated premixes intended for animal feed incorporation, developed through international harmonization standards.
- Agency Information Collection Activities: Notice of Request for Reinstatement of a Previously Approved Information CollectionApril 16, 2026
Federal Highway Administration seeks OMB reinstatement of a previously approved information collection under the Paperwork Reduction Act of 1995.
- Establishment of Class E Airspace; Freer, TXApril 16, 2026
FAA proposes establishing Class E airspace at Freer, TX to support new instrument procedures and IFR operations for aviation safety and efficiency.
- Imposition of Special Measure Prohibiting Certain Transmittals of Funds Involving CIBanco S.A., Institución de Banca Multiple; AmendmentApril 16, 2026
FinCEN's amended special measure on CIBanco S.A. permits certain fund transmittals to allow the Mexican government to liquidate the institution while maintaining restrictions on other transfers related to money laundering concerns.
- Proposed New and Renewal of Agency Information Collections; Request for CommentsApril 16, 2026
The National Credit Union Administration seeks OMB renewal of existing information collections under the Paperwork Reduction Act of 1995; credit unions should review proposed extensions and revisions.
- Notice of Public Meeting of the Alaska Advisory Committee to the U.S. Commission on Civil RightsApril 16, 2026
Alaska Advisory Committee to the U.S. Commission on Civil Rights will hold Zoom meetings to discuss and vote on a project proposal regarding ranked choice voting in Alaska.
- Notice of Suspension and Commencement of Proposed Debarment ProceedingsApril 16, 2026
The FCC Enforcement Bureau suspends Charles A. Jones from the E-Rate Program and all universal service support mechanisms, commencing debarment proceedings against him and any entity contracting with him.
- Agency Information Collection Activities; Comment Request; Private School Universe Survey (PSS) 2025-26 and 2027-28 Data Collections, and 2027-28 PSS Frame Development ActivitiesApril 16, 2026
Department of Education requests public comment on the Private School Universe Survey data collection for 2025-26 and 2027-28 school years under the Paperwork Reduction Act.
- Information Collection; SF-299 Application for Transportation, Utility Systems, Telecommunications and Facilities on Federal Lands and PropertyApril 16, 2026
Forest Service seeks public comment on extending the SF-299 application form for permits to operate transportation, utility, telecommunications, and facility systems on federal lands and property.
- Agency Information Collection Activities: Request for Comments for a New Information CollectionApril 16, 2026
Federal Highway Administration requests public comments on a new information collection by the Paperwork Reduction Act deadline before seeking Office of Management and Budget approval.
- Privacy Act of 1974; System of RecordsApril 16, 2026
EPA's Office of Finance and Administration is modifying its Compass system of records to add a new routine use for debt collection, accounts payable, and budget tracking as required by Executive Order 14249 and OMB Memorandum M-25-32.
- Air Plan Revisions; Arizona; Maricopa County Air Quality Department; New Source Review; Emission Reduction CreditsApril 16, 2026 • Impact: low
EPA proposes to approve Arizona's Maricopa County Air Quality Department revision allowing fleet owners to generate emission reduction credits through vehicle retrofits or replacements for use as offsets in the Nonattainment New Source Review progra…